A new tandem catalytic process has been established for the synthesis of quinolines.
This process utilizes the [IrCp*Cl2]2/KOH catalyzed isomerization/cyclization of allylic alcohols with 2-aminobenzyl alcohol.
Both the secondary and primary allylic alcohols were investigated in this catalytic
system to afford different substituted quinoline derivatives in moderate to good yields.
A mechanism study showed the reaction following a tandem process integrating isomerization
of allylic alcohols and oxidative cyclization of 2-aminobenzyl alcohol.
Key words
iridium - quinolines - allylic alcohol - isomerization - cyclization